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The outcome of the clinical decision-making process involves the health professional deciding on the way forward 100 ml mentat ds syrup mastercard treatment rheumatoid arthritis. Weinman (1987) suggested that it is important to realize that the outcome of a consultation and a diagnosis is not an absolute entity cheap mentat ds syrup 100 ml on-line medicine 852, but is itself a hypothesis and an informed guess that will be either confirmed or refuted by future events. Explaining variability Variability in the behaviour of health professionals can therefore be understood in terms of the processes involved in clinical decisions. For example, health professionals may: s access different information about the patient’s symptoms; s develop different hypotheses; s access different attributes either to confirm or to refute their hypotheses; s have differing degrees of a bias towards confirmation; s consequently reach different management decisions. Explaining variability – the role of health professionals’ health beliefs The hypothesis testing model of clinical decision making provides some understanding of the possible causes of variability in health professional behaviour. Perhaps the most important stage in the model that may lead to variability is the development of the original hypothesis. Health professionals are usually described as having professional beliefs, which are often assumed to be consistent and predictable. However, the development of the original hypothesis involves the health professional’s own health beliefs, which may vary as much as those of the patient. Components of models such as the health belief model, the protection motivation theory and attribution theory have been developed to examine health professionals’ beliefs. The beliefs involved in making the original hypothesis can be categorized as follows: 1 The health professional’s own beliefs about the nature of clinical problems. For example, if a health professional believes that health and illness are determined by biomedical factors (e. However, a health professional who views health and illness as relating to psychosocial factors may develop hypotheses reflecting this perspective (e. Health professionals will have pre-existing beliefs about the prevalence and incidence of any given health problem that will influence the process of developing a hypothesis. For example, some doctors may regard childhood asthma as a common complaint and hypothesize that a child presenting with a cough has asthma, whereas others may believe that childhood asthma is rare and so will not consider this hypothesis. Weinman (1987) argued that health professionals are motivated to consider the ‘pay-off’ involved in reaching a correct diagnosis and that this will influence their choice of hypothesis. He suggested that this pay-off is related to their beliefs about the seriousness and treatability of an illness. For example, a child presenting with abdominal pain may result in an original hypothesis of appendicitis as this is both a serious and treatable condition, and the benefits of arriving at the correct diagnosis for this condition far outweigh the costs involved (such as time-wasting) if this hypothesis is refuted. Marteau and Baum (1984) have argued that health professionals vary in their perceptions of the serious- ness of diabetes and that these beliefs will influence their recommendations for treatment. Brewin (1984) carried out a study looking at the relationship between medical students’ perceptions of the controllability of a patient’s life events and the hypothetical prescription of antidepressants. The results showed that the students reported variability in their beliefs about the controllability of life events; if the patient was seen not to be in control (i. This suggests that not only do health professionals report inconsistency and variability in their beliefs, this variability may be translated into variability in their behaviour. The original hypothesis will also be related to the health professional’s existing knowledge of the patient. Such factors may include the patient’s medical history, knowledge about their psychological state, an under- standing of their psychosocial environment and a belief about why the patient uses the medical services. Stereotypes are sometimes seen as problematic and as confounding the decision-making process. However, most meet- ings between health professionals and patients are time-limited and consequently stereotypes play a central role in developing and testing a hypothesis and reaching a management decision. Stereotypes reflect the process of ‘cognitive economy’ and may be developed according to a multitude of factors such as how the patient looks/talks/ walks or whether they remind the health professional of previous patients. Without stereotypes, consultations between health professionals and patients would be extremely time-consuming. Other factors which may influence the development of the original hypothesis include: 1 The health professional’s mood. The health professional’s mood may influence the choice of hypotheses and the subsequent process of testing this hypothesis.

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Many patients try home remedies to battle the rhinovirus buy generic mentat ds syrup 100 ml on-line treatment hiatal hernia, however these don’t affect the virus buy generic mentat ds syrup 100 ml medicine 911. Home remedies include rest, vitamin C, mega doses of other vitamins, and, of course, chicken soup. Vitamin C and mega doses of other vitamins have not been proven effective against the common cold. When home remedies fail, patients turn to both prescription and over-the- counter medication. Charts throughout these pages provide information about specific drugs in each group. Antihistamines (H blocker) 1 Many cold symptoms are caused by the body’s overproduction of histamines. Histamines are potent vasodilators that react to a foreign substance in the body such as the rhinovirus. H2 receptors cause an increase in gastric secretions and are not involved in this response. This is referred to as nasal con- gestion and is caused when the nasal mucous membranes swell in response to the rhinovirus. A decongestant is a drug that stimulates the alpha-adrenergic receptors to tell the brain to constrict the capillaries within the nasal mucosa. The result is that the nasal mucous membranes shrink, reducing the amount of fluid that is secreted from the nose. Decongestants are available in nasal spray, drops, tablets, capsules, or in liq- uid form. These are nasal decongestants that provide quick relief to the patient; systemic decongestants that provide a longer lasting relief from congestion; and intranasal glucocorticoids that are used to treat seasonal and perennial rhinitis. Cough Preparations A cough is a common symptom of a cold brought about by the body’s effort to remove nasal mucous that might drain into the respiratory tract. Antitussives are the ingredients used in cough medicine to suppress the cough center in the medulla. Although the cough reflex is useful to clear the air passages, suppres- sion of the cough reflex can provide some rest for the patient. Expectorants When an individual has a cold or other respiratory infection, it is common to have rather thick mucous that is difficult to expectorate. Expectorants are med- ications that loosen the secretions making it easier for the patient to cough up and expel the mucous. They work by increasing the fluid output of the respira- tory tract and decrease the adhesiveness and surface tension to promote removal of viscous mucus. A list of drugs utilized in the treatment of upper respiratory tract disorders is provided in the Appendix. Patients may take systemic or nasal decongestants to reduce the congestion that frequently accompanies sinusitis. Patients are told to drink plenty of fluids, to rest, and to take acetaminophen (Tylenol) or ibupro- fen for discomfort. In some cases, antibiotics are prescribed if the condition is severe or long lasting and an infection is suspected. Pharyngitis is caused by a virus (viral pharyngitis) or by bacteria (bacteria pharyngitis) such as the beta-hemolytic streptococci. Sometimes patients experience acute pharyngitis along with other upper respiratory tract disease such as a cold, rhinitis, or acute sinusitis. Patients who have a viral pharyngitis are given medications that treat the symptoms rather than attacking the underlying virus. Acetaminophen or ibupro- fen is given to reduce the patient’s temperature and discomfort. Saline gargles, lozenges, and increased fluid are usually helpful to soothe the sore throat. Patients who have bacterial pharyngitis are given antibiotics to destroy the beta-hemolytic streptococci bacteria. However, antibiotics are only prescribed if the result of the throat culture is positive for bacteria.

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Rod and cone cells are the light sensitive receptor cells in the retina of the human eye mentat ds syrup 100 ml lowest price treatment xanthelasma. About three million rod cells are responsible for our vision in dim light purchase mentat ds syrup 100 ml without prescription treatment impetigo, whereas the hundred million cone cells are responsible for our vision in the bright light and for the perception of bright colours. This cis–trans isomerization is accompanied by an alteration in molecular geometry, which generates a nerve impulse to be sent to the brain, resulting in the perception of vision. Well, all these drugs and many other important drugs belong to the class of compounds called steroids. They are synthesized in glands and delivered by the bloodstream to target tissues to stimulate or inhibit some process. Their nonpolar character allows them to cross cell membranes, so they can leave the cells in which they are synthesized and enter their target cells. Hundreds of distinct steroids have been identified in plants, animals and fungi, and most of them have interesting biological activity. They have a common basic ring structures, three-fused cyclohexane rings, together the phenanthrene part, fused to a cyclopentane ring system, known as cyclopentaphenanthrene. The four rings are lettered A, B, C and D, and the carbon atoms are numbered beginning in the A ring as shown in gonane. Androstane Pregnane Cholane A C19 steroid A C21 steroid A C steroid 24 Many steroids have an alcoholic hydroxyl attached to the ring system, and are known as sterols. There are many different steroid hormones, and cholesterol is the precursor for all of them. Barton of Great Britain received the Nobel Prize in 1969 for recognizing that functional groups could vary in reactivity depending on whether they occupied an axial or an equatorial position on a ring (see Chapter 3). All three of the six- membered rings can adopt strain-free chair conformations as shown below. Unlike simple cyclohexane rings, which can undergo chair–chair interconver- sions, steroids, being the large rigid molecules cannot undergo ring-flips. Steroids can have either cis or trans fusion of the A and B rings; both kind of steroid are relatively long, flat molecules but the A, B trans-fused steroids are by far the more common, though cis-fused steroids are found in bile. Furthermore, the presence of two angular methyl groups at C-10 and C-13 positions is characteristic in cholesterol. Substituents on the steroid ring system may be either axial or equatorial, and as usual equatorial substitution is more favourable than axial substitution for steric reasons. Thus, the hydroxyl group at C-3 of cholesterol has the more stable equatorial orientation. The lower side of the steroid is denoted a, the upper side of the steroid is denoted b, usually drawn as projected below the plane of the paper, which is shown as broken lines, and above the plane of the paper, which is drawn as solid lines. Cholesterol has eight chiral centres, therefore 256 stereoisomers are theoretically possible, but only one exists in nature! Stereogenic centres in steroid side chains are denoted preferentially with the R and S nomenclature. However, with the increase in number of hydroxyl or other polar functional groups on the steroid skeleton, the solubility in polar solvents increases. Glucocorti- coids are a class of steroid hormones characterized by an ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids regulate many aspects of metabolism and immune functions, and are 6. Rather than a head-to-tail arrangement of six units of isoprene, there appear to be farnesyl units that have been connected tail to tail. Cholesterol is biosynthesized from squalene, which is first converted to lanosterol. The conversion of squalene to the steroid skeleton is an oxirane, squalene-2,3-oxide, which is trans- formed by enzymes into lanosterol, a steroid alcohol naturally found in wool fat. Squalene is an important biological precursor of many triterpenoids, one of which is cholesterol. The first step in the conversion of squalene to lanosterol is epoxidation of the 2,3-double bond of squalene. Acid-catalysed ring opening of the epoxide initiates a series of cyclizations, resulting in the formation of protesterol cation. Elimination of a C-9 proton leads to the 1,2- hydride and 1,2-methyl shifts, resulting in the formation of lanosterol, which in turn converted to cholesterol by enzymes in a series of 19 steps.

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